A whole-blueberry ingredient marketed by Givaudan as ThinkBlue was associated with improvements in certain measures of mild cognitive impairment in a population of healthy adults between the ages of 68 and 75. across two clinical trials published in Nutrients. The low-dose wild blueberry formulation is standardized to high concentrations of polyphenols, which are associated with improvements in cognitive function.<\/p>\n\n\n\n
Mild cognitive impairment (MCI) is part of the aging process, with 17% of those 65 years and older experiencing impacts on reasoning, memory, and processing speed.<\/p>\n\n\n\n
In order to assess the efficacy of the blueberry ingredient, Givaudan and the team of researchers at the University of Reading conducted two new studies to evaluate immediate effects.<\/p>\n\n\n\n
The first study examined a range of wild blueberry extract doses in order to identify the optimal dose to use for maintaining measures of executive function, episodic memory, and cardiovascular outcomes. Participants received a single dose of either 111 mg, 222 mg, 444 mg, or 888 mg, or a placebo over a five-week period, with each dose separated by a one-week washout. Compared to placebo, supplements containing 222 mg or more produced significant reductions in systolic and diastolic blood pressure compared to placebo, and all blueberry doses attenuated a post-lunch dip in cognitive decline performance, which was only observed in the placebo group.<\/p>\n\n\n\n
With an optimal dosage of 222 mg identified in the first study, the second study tested a 222 mg dose in 45 participants versus placebo, with outcomes measured at baseline and again when the post-lunch dip was anticipated. Lunch was consumed an hour prior to cognitive testing in order to enhance the results. In the second study, a significant dip in executive function was apparent in only the placebo group, with executive functioning reaction time achieving clinical significance.<\/p>\n\n\n\n
\u201cThese two studies indicate that [whole berry extract] may have cardiovascular benefits and attenuate the natural cognitive decline observed over the course of the day, particularly when a decline is associated with a circadian rhythm-driven postprandial dip. However, it is important to acknowledge that effects were subtle, and benefits were only observed in a small number of outcomes,\u201d the authors concluded, noting that further research is needed.<\/p>\n","protected":false},"excerpt":{"rendered":"
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