As a methylated derivative of hesperidin, methyl hesperidin has multidimensional value in its pharmacological effects and clinical applications. The details are as follows:
1. Core pharmacological effects
Antioxidant and free radical scavenging
By enhancing the activity of intracellular antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), it reduces the lipid peroxidation products (e.g. malondialdehyde MDA), and counteracts oxidative stress damage.
Application scenarios: delay aging, protect cardiovascular endothelial cells, reduce skin damage caused by UV radiation.
Anti-inflammatory and immunomodulation
Inhibit nuclear factor κB (NF-κB) signaling pathway, reduce the release of pro-inflammatory factors such as tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6).
Clinical evidence: Improve inflammatory diseases such as chronic gastritis and oral ulcers, and assist in regulating immune function.
Antiviral and antibacterial
Inhibit the neuraminidase activity of influenza A virus (H1N1). In vitro experiments show that it can inhibit the growth of bacteria such as Staphylococcus aureus and Escherichia coli.
Daily chemical application: toothpaste containing 0.1% methyl hesperidin can inhibit oral pathogenic bacteria and reduce the risk of dental caries.
Cardiovascular protection
Improve hemodynamics: dilate coronary arteries, increase myocardial blood supply, relieve angina symptoms.
Anti-atherosclerosis: inhibits oxidized low-density lipoprotein (ox-LDL)-induced foam cell formation and slows plaque progression.
Capillary Strengthening: Enhance the elasticity of capillary wall, reduce permeability, improve microcirculation disorders such as diabetic retinopathy and varicose veins.
Skin whitening and repair
Inhibit tyrosinase activity and expression of melanin synthesis-related genes (e.g. MITF) to reduce pigmentation.
Promote the proliferation of skin fibroblasts, accelerate wound healing, and improve the symptoms of redness and sensitive skin.
2. The main clinical applications
Cardiovascular system diseases
Chronic heart failure: Combined with digoxin, it can improve cardiac function classification (NYHA) and increase ejection fraction (EF).
Coronary heart disease: auxiliary relief of stable angina, reduce myocardial oxygen consumption.
Hypertension: synergistic use with vitamin C can improve vascular endothelial function and assist in lowering blood pressure.
Skin Related Diseases
Melasma/freckles: Topical preparations (e.g. 2% methyl hesperidin cream) can reduce pigmented area by 35%-42% after 8 weeks of use.
Seborrheic dermatitis: Improvement of facial erythema and scaling symptoms through anti-inflammation and regulation of sebum secretion.
Oral health
Toothpaste additives: 0.1% concentration can inhibit plaque formation and reduce the Gum Bleeding Index (GBI) by about 40%.
Oral ulcers: use in the form of a gargle can accelerate mucosal repair and shorten the duration of ulcers.
Daily chemical and beauty
Whitening Essence: Compounded with niacinamide and α-arbutin, the essence improves UV-induced hyperpigmentation better than a single ingredient.
Anti-hair loss shampoo: synergized with vitamin C and biotin to improve scalp microcirculation and promote hair growth.