Methyl Hesperidin is a derivative of the flavonoid hesperidin extracted from the rind of citrus fruits that has been modified by methylation. The development and application of its derivatives are mainly focused on the improvement of solubility, enhancement of biological activity and expansion of functional properties. The following are some of the main derivatives of methyl hesperidin and their application directions:
1. Methyl Hesperidin Chalcone
Structural characteristics: Methylhesperidin Chalcone is a chalcone derivative obtained by modifying the chemical structure of methylhesperidin. The chalcone structure has enhanced antioxidant and anti-inflammatory activity.
Bioactivity:
Antioxidant: the conjugated double bond system in the chalcone structure enhances its free radical scavenging ability.
Anti-inflammatory: It inhibits the release of inflammatory factors and reduces the inflammatory response.
Whitening: It has whitening effect by inhibiting tyrosinase activity and reducing melanin production.
Application: Widely used in cosmetics (such as whitening products), health care products and functional foods.
2. Methyl Hesperidin Dihydrochalcone
Structural characteristics: Dihydrochalcone is the reduction product of chalcone, with higher stability and water solubility.
Biological activity:
Sweetener: Intensely sweet, hundreds of times sweeter than sucrose, can be used as a low-calorie sweetener.
Antioxidant: retains the antioxidant activity of hesperidin.
Applications: Mainly used in the food industry as a sweetener and flavor modifier, also used in pharmaceuticals and cosmetics.
3. Methyl Hesperidin Sulfate
Structural features: Sulfate groups are introduced into the molecule of methylhesperidin by sulfation reaction.
Biological activity:
Anticoagulant: Sulfate esterification can enhance its anticoagulant activity.
Antiviral: It has an inhibitory effect on certain viruses.
Applications: Mainly used in drug development, especially in the field of anticoagulant and antiviral.
4. Methyl Hesperidin Glucoside
Structural features: Glucose molecules are attached to methyl hesperidin through glycosidic bonds.
Biological Activity: Enhanced water solubility: The introduction of glucoside improves the water solubility of the compound and facilitates its absorption in living organisms.
Antioxidant: The antioxidant activity of hesperidin is retained.
Applications: Used in functional foods and pharmaceuticals as antioxidants and nutritional supplements.
5. Methyl Hesperidin Fatty Acid Esters
Structural features: Fatty acids are attached to methyl hesperidin by esterification reaction.
Biological activity:
Emulsifying properties: the introduction of fatty acid esters enhances the emulsifying properties of the compound.
Bioavailability: may improve the bioavailability of methyl hesperidin.
Applications: mainly used in the food industry as emulsifier and stabilizer, also used in cosmetics.
6. Methyl Hesperidin Amino Acid Derivatives
Structural features: amino acids are attached to methyl hesperidin by chemical reaction.
Biological activity:
Targeted delivery: the introduction of amino acids may enhance the targeting of compounds to specific cells or tissues.
Bioactivity enhancement: may improve antioxidant, anti-inflammatory and other activities.
Applications: mainly used in drug discovery and development, especially in the field of targeted therapy and nutritional supplementation.